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Index > Protein center > CDK11A(Gene name) > Human
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  • CDK11A (Gene name),
  • Cyclin-dependent kinase 11A (Protein name ),  CD11A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CDK11A(CDC2L2;CDC2L3;PITSLREB);
    Protein name:
    Cyclin-dependent kinase 11A;
    Alternative:
    Cell division protein kinase 11A;Cell division cycle 2-like protein kinase 2;PITSLRE serine/threonine-protein kinase CDC2L2;Galactosyltransferase-associated protein kinase p58/GTA;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    The cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1. The p58 isoform but not the p110 isoform or p110C interacts with CCND3. The p110 isoforms are found in large molecular weight complexes containing CCNL1 and SFRS7.
    Function:
    Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    783
    Sequence:
    50:
    MGDEKDSWKV | KTLDEILQEK | KRRKEQEEKA | EIKRLKNSDD | RDSKRDSLEE | 
    100:
    GELRDHCMEI | TIRNSPYRRE | DSMEDRGEED | DSLAIKPPQQ | MSRKEKVHHR | 
    150:
    KDEKRKEKWK | HARVKEREHE | RRKRHREEQD | KARREWERQK | RREMAREHSR | 
    200:
    RERDRLEQLE | RKRERERKMR | EQQKEQREQK | ERERRAEERR | KEREARREVS | 
    250:
    AHHRTMREDY | SDKVKASHWS | RSPPRPPRER | FELGDGRKPG | EARPAPAQKP | 
    300:
    AQLKEEKMEE | RDLLSDLQDI | SDSERKTSSA | ESSSAESGSG | SEEEEEEEEE | 
    350:
    EEEEGSTSEE | SEEEEEEEEE | EEEETGSNSE | EASEQSAEEV | SEEEMSEDEE | 
    400:
    RENENHLLVV | PESRFDRDSG | ESEEAEEEVG | EGTPQSSALT | EGDYVPDSPA | 
    450:
    LLPIELKQEL | PKYLPALQGC | RSVEEFQCLN | RIEEGTYGVV | YRAKDKKTDE | 
    500:
    IVALKRLKME | KEKEGFPITS | LREINTILKA | QHPNIVTVRE | IVVGSNMDKI | 
    550:
    YIVMNYVEHD | LKSLMETMKQ | PFLPGEVKTL | MIQLLRGVKH | LHDNWILHRD | 
    600:
    LKTSNLLLSH | AGILKVGDFG | LAREYGSPLK | AYTPVVVTQW | YRAPELLLGA | 
    650:
    KEYSTAVDMW | SVGCIFGELL | TQKPLFPGNS | EIDQINKVFK | ELGTPSEKIW | 
    700:
    PGYSELPVVK | KMTFSEHPYN | NLRKRFGALL | SDQGFDLMNK | FLTYFPGRRI | 
    750:
    SAEDGLKHEY | FRETPLPIDP | SMFPTWPAKS | EQQRVKRGTS | PRPPEGGLGY | 
    783:
    SQLGDDDLKE | TGFHLTTTNQ | GASAAGPGFS | LKF
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    MIM:
    String:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cyclin-dependent kinase 11A
    Cat.:
    E11150h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Cyclin-dependent kinase 11A
    Cat.:
    U11150h
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Cyclin-dependent kinase 11A
    Cat.:
    P11150Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Cyclin-dependent kinase 11A
    Protein for Human Cyclin-dependent kinase 11A

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms."
      Xiang J. , Lahti J.M. , Grenet J.A. , Easton J.B. , Kidd V.J.
      J. Biol. Chem.269:15786-15794(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SV1; SV2 AND 4);TISSUE SPECIFICITY;SUBCELLULAR LOCATION;VARIANT SER-402
      tissue: Cervix carcinoma.
    2. 2.
      "Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2."
      Gururajan R. , Lahti J.M. , Grenet J.A. , Easton J. , Gruber I. , Ambros P.F. , Kidd V.J.
      Genome Res.8:929-939(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SV1; SV2; SV3; SV6; SV7; SV12 AND SV13);TISSUE SPECIFICITY;VARIANT TRP-93
      tissue: Cervix carcinoma.
    3. 3.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT TRP-93
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SV7)
      tissue: Skin.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH CCNL1 AND SFRS7
    6. 6.
      "Identification and characterization of a novel cell cycle-regulated internal ribosome entry site."
      Cornelis S. , Bruynooghe Y. , Denecker G. , Van Huffel S. , Tinton S. , Beyaert R.
      Mol. Cell5:597-605(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE INITIATION (ISOFORM 4);INDUCTION
    7. 7.
      "The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis."
      Chen S. , Yin X. , Zhu X. , Yan J. , Ji S. , Chen C. , Cai M. , Zhang S. , Zong H. , Hu Y. , Yuan Z. , Shen Z. , Gu J.
      J. Biol. Chem.278:20029-20036(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PAK1
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